5-Amino-1MQ (5-amino-1-methylquinolinium)

What it is

Blocks nicotinamide N-methyltransferase (NNMT), an enzyme linked to cell metabolism and energy balance. In cultured fat cells, it reduced fat formation and raised NAD+ and SAM levels at some concentrations; these are laboratory findings.

What it is studied for

Researchers have tested it in obese mice fed a high-fat diet and in aged mice. One study measured muscle repair after injury in 24-month-old mice; another compared it with and without intensive exercise in older mice.

What the evidence says

Animal and cell studies only

In an 11-day study of 9 obese mice per group, treated mice lost about 5% of body weight while controls gained slightly, with no change in food intake. Aged mice showed better muscle regeneration and grip strength. None of these results come from people. The three cited studies share authors; three 2024 authors declared roles at Ridgeline Therapeutics.

How it was studied

The mouse studies gave 5-amino-1MQ by injection under the skin. Dissolving strips, alone or combined with NAD+ and MOTS-c, were not the form studied.