Detox: what the research says about Glutathione
Glutathione: An antioxidant tripeptide the body makes itself; small trials of oral and intranasal glutathione show mixed or no clear benefits.
Detox from USA Standard Research: nasal spray, Glutathione 500 mg per 10 mL bottle. Sold for research use only.
Editorial discussion starter: which finding would you like explained, and what does the research leave open? Share public sources. Please leave out personal medical details and dosing.
The research
Glutathione
An antioxidant tripeptide the body makes itself; small trials of oral and intranasal glutathione show mixed or no clear benefits.
Small human trials with mixed results
What it is studied for
Trials have tested whether oral glutathione raises the body's own levels or lowers oxidative stress in healthy adults, and whether intranasal glutathione helps people with Parkinson's disease, in which glutathione is depleted early. FDA's 2022 review also covered uses such as heavy-metal poisoning and skin lightening.
What the evidence says
A 6-month trial in 54 adults found oral glutathione raised blood levels, which fell back after stopping; a 4-week trial in 40 adults found no change. In a 45-person Parkinson's trial, intranasal glutathione did no better than saline. FDA found no or insufficient evidence for every use it reviewed, including oxidative stress and heavy-metal poisoning.
Detox
- Nasal spray Glutathione 500 mg per 10 mL bottle
Sold by USA Standard Research, the team behind PeptidesGenie, for research use only. Not for human or veterinary use.
Research cited
- 1
- 2
- 3Mischley et al. (2017): Phase IIb study of intranasal glutathione in Parkinson's disease Randomized human trial
- 4